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5-Amino-1MQ
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Immune Modulation
Research chemical
KPV
Also known as: Lys-Pro-Val, α-MSH (11-13)
KPV is a small tripeptide (Lysine-Proline-Valine) that is the C-terminal fragment of alpha-MSH (alpha-melanocyte-stimulating hormone). It carries the potent anti-inflammatory and immunomodulatory activity of alpha-MSH without the pigmentation effects. KPV is particularly known for gut inflammation control, skin conditions, and the gut-skin axis.
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$55
10mg
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KPV is a small tripeptide (Lysine-Proline-Valine) that is the C-terminal fragment of alpha-MSH (alpha-melanocyte-stimulating hormone). It carries the potent anti-inflammatory and immunomodulatory activity of alpha-MSH without the pigmentation effects. KPV is particularly known for gut inflammation control, skin conditions, and the gut-skin axis.
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Half-Life
~15–30 minutes
Common Dose
200–500 mcg per day
Route
Subcutaneous injection
Frequency
Once daily
Mechanism of Action
KPV enters cells and acts on melanocortin receptors (MC1R, MC3R), suppressing NF-kB signaling and pro-inflammatory cytokines (TNF-α, IL-6, IL-8). It reduces inflammation at the source of immune cell activation. Particularly effective on intestinal epithelial cells, which is why it is often used for IBD, leaky gut, and inflammatory bowel issues.
Reported Benefits
- ✦Powerful anti-inflammatory effects
- ✦Gut barrier repair and IBD/colitis support
- ✦Acne and skin inflammation reduction
- ✦Improves the gut-skin axis
- ✦Wound healing support
- ✦Anti-microbial activity
- ✦Generally very well-tolerated
Dosage Protocol
Common dose200–500 mcg per day
Range200–1000 mcg per day
FrequencyOnce daily
AdministrationSubcutaneous injection
Notes
10 mg vial — reconstitute with 2 mL bac water → 5 mg/mL: 10 units (0.1 mL) = 500 mcg. Cycle 4–8 weeks.
Research Status
Several decades of research in inflammation, IBD, and dermatology. Not yet approved as a pharmaceutical.
Storage
Lyophilized: refrigerate. Reconstituted: refrigerate, use within 30 days.
Legal Status
Research chemical. Not approved for human therapeutic use.
Commonly Stacked With
Dose Calculator
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Quick Reference
1 mg= 1,000 mcg
1 mL= 100 units (on a 100u syringe)
1 mL= 1 cc
Common reconstitution1–3 mL BAC water per vial
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Research use only. This tool is a mathematical reference for trained laboratory personnel. It does not recommend a dose, injection volume, treatment, or human use. Always follow your approved protocol, product documentation, and applicable regulations.
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For laboratory research purposes only. Not for human use. Not medical advice.