Cognitive & Neuroprotection Approved pharmaceutical in Russia

Semax

Also known as: Met-Glu-His-Phe-Pro-Gly-Pro, ACTH (4-10) analog

Semax is a synthetic heptapeptide developed in Russia, based on a fragment of ACTH (adrenocorticotropic hormone) but without hormonal effects. It is one of the most well-known nootropic peptides — used for cognitive enhancement, focus, memory, neuroprotection, and stroke recovery. Approved as a pharmaceutical in Russia for neurological and cognitive disorders.

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$50

10mg

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Half-Life

Short systemic, but CNS effects last hours

Common Dose

250–600 mcg per day (subcutaneous)

Route

Subcutaneous injection

Frequency

1–3 times per day

Mechanism of Action

Semax increases BDNF (brain-derived neurotrophic factor) and NGF (nerve growth factor) — key proteins for neuronal growth, plasticity, and survival. It also modulates dopamine and serotonin neurotransmission, enhances cerebral blood flow, and has antioxidant and neuroprotective effects in the brain.

Reported Benefits

✦Enhanced cognition, memory, and learning
✦Improved focus and attention
✦Neuroprotection and stroke recovery support
✦Mood and motivation enhancement
✦Stress and fatigue reduction
✦Increased BDNF and NGF
✦Anti-inflammatory effects in the brain

Dosage Protocol

Common dose250–600 mcg per day (subcutaneous)

Range250 mcg–1.5 mg per day, divided

Frequency1–3 times per day, morning/afternoon preferred

AdministrationSubcutaneous injection

Notes

10 mg vial reconstituted with 2 mL bac water → 5 mg/mL: 5 units (0.05 mL) = 250 mcg. Cycle 2–4 weeks on, 1–2 weeks off, or use as needed.

Research Status

Approved pharmaceutical in Russia for stroke, cognitive disorders, and optic nerve atrophy. Limited Western clinical data.

Storage

Lyophilized: refrigerate. Reconstituted: refrigerate, use within 30 days.

Legal Status

Approved pharmaceutical in Russia. Research chemical elsewhere.

Commonly Stacked With

Selank DSIP

DSIP

Cognitive & Neuroprotection

Selank

Cognitive & Neuroprotection

Dose Calculator

Pre-filled with Semax's vial size. Enter your water volume and desired dose to see exactly how many units to draw.

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Total milligrams in the vial (check the label)

Water Added (mL)

Bacteriostatic water added to reconstitute

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Quick Reference

1 mg= 1,000 mcg

1 mL= 100 units (on a 100u syringe)

1 mL= 1 cc

Common reconstitution1–3 mL BAC water per vial

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Research use only. This tool is a mathematical reference for trained laboratory personnel. It does not recommend a dose, injection volume, treatment, or human use. Always follow your approved protocol, product documentation, and applicable regulations.