DSIP
Also known as: Delta Sleep-Inducing Peptide
DSIP (Delta Sleep-Inducing Peptide) is a 9-amino-acid neuropeptide first isolated from the cerebral venous blood of sleeping rabbits. As its name suggests, it promotes the delta-wave (deep, restorative) phase of sleep and has additional effects on stress reduction, pain modulation, and hormonal balance. Used by individuals with sleep disturbances, jet lag, or chronic stress.
Research Use Only
Pricing
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Credit card accepted · For research & educational use only — not for human consumption.
Half-Life
~30 minutes (but effects on sleep persist longer)
Common Dose
100–300 mcg per night
Route
Subcutaneous injection
Frequency
Once daily
Mechanism of Action
The exact mechanism is not fully understood, but DSIP appears to modulate GABAergic activity, influence circadian rhythm regulation, reduce cortisol secretion, and increase delta-wave EEG activity during sleep. It also has analgesic and stress-buffering effects via interaction with the HPA axis.
Reported Benefits
- ✦Promotes deep, restorative sleep (delta phase)
- ✦Reduces sleep onset time
- ✦Helps with jet lag and shift work adjustment
- ✦Lowers cortisol and stress response
- ✦Mild analgesic effects
- ✦May improve mood
- ✦Non-addictive sleep aid
Side Effects
- !Generally very well-tolerated
- !Mild lightheadedness (rare)
- !Drowsiness (intended effect)
- !Injection site irritation
Dosage Protocol
Notes
Reconstitute per provider protocol. Effects are subtle — best evaluated over 1–2 weeks of consistent use. Can be cycled or used as needed for sleep issues, recovery phases, or stress periods.
Research Status
Several decades of research, including human studies for sleep, alcoholism, and chronic pain. Not approved as a pharmaceutical.
Contraindications
- ✕Pregnancy and breastfeeding
- ✕Known hypersensitivity
- ✕Caution when combined with other sedatives
Storage
Lyophilized: refrigerate. Reconstituted: refrigerate, use within 30 days.
Legal Status
Research chemical. Not approved for human therapeutic use.
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