NAD+
Also known as: Nicotinamide Adenine Dinucleotide, NAD Plus
NAD+ is a critical coenzyme found in every cell of the body, essential for energy production, DNA repair, and cellular signaling. Levels decline dramatically with age, contributing to fatigue, metabolic decline, and accelerated aging. Injectable NAD+ bypasses poor oral absorption to directly restore cellular NAD+ levels — popular for energy, cognitive function, recovery, and longevity.
Research Use Only
Pricing
10-Pack Bundle Save 20%
Credit card accepted · For research & educational use only — not for human consumption.
Half-Life
Plasma half-life varies; cellular effects persist
Common Dose
50–250 mg per session (SC); 250–500 mg per IV session
Route
Subcutaneous injection or IV infusion (IV most effective for large doses)
Frequency
Daily SC microdoses or 1–3x weekly larger doses
Mechanism of Action
NAD+ is required for over 500 enzymatic reactions, including those of sirtuins (longevity proteins) and PARPs (DNA repair enzymes). It is essential for mitochondrial electron transport and ATP production. Restoring NAD+ levels reactivates sirtuin-mediated longevity pathways, improves mitochondrial function, supports DNA repair, and enhances overall cellular metabolism.
Reported Benefits
- ✦Increased energy and reduced fatigue
- ✦Cognitive enhancement and mental clarity
- ✦Anti-aging via sirtuin activation
- ✦DNA repair support
- ✦Mitochondrial health and biogenesis
- ✦Improved metabolic function
- ✦Used in addiction recovery and chronic fatigue protocols
- ✦Athletic recovery and performance
Side Effects
- !Flushing, chest tightness, or nausea (especially with fast IV push)
- !Injection site irritation (SC)
- !Headache or dizziness
- !Effects typically reduced by slow administration
Dosage Protocol
Notes
500 mg vial — reconstitute per provider protocol. SC dosing: start with 50–100 mg and titrate up to assess tolerance (flushing is common). IV infusions typically run 250–500 mg over 1–4 hours. Cycle 4–8 weeks or use as needed for energy/recovery.
Research Status
Active research in aging, neurodegenerative disease, and metabolic health. Used clinically in IV therapy and addiction recovery.
Contraindications
- ✕Pregnancy and breastfeeding (limited data)
- ✕Active malignancy (theoretical concerns about cellular energetics)
- ✕Known hypersensitivity
Storage
Lyophilized: refrigerate, protect from light. Reconstituted: refrigerate, use within 14 days.
Legal Status
Available via compounding pharmacies and IV therapy clinics. Not FDA-approved as a drug.
Dose Calculator
Pre-filled with NAD+'s vial size. Enter your water volume and desired dose to see exactly how many units to draw.
Total milligrams in the vial (check the label)
Bacteriostatic water added to reconstitute
Micrograms you want per injection
Insulin syringe capacity
Results
Concentration
—mcg/mL
Volume to Inject
—mL
Draw to Mark
—units
Doses per Vial
—doses
Fill in all fields above to see your results.
