Tesamorelin
Also known as: Egrifta, TH9507
Tesamorelin is a synthetic analog of GHRH (growth hormone-releasing hormone) and the only GHRH analog FDA-approved for clinical use (under the brand name Egrifta, for HIV-associated lipodystrophy). It produces strong, physiologic GH release and is especially noted for reducing visceral (deep belly) fat — making it popular for body recomposition, cognitive benefits, and metabolic health.
Research Use Only
Pricing
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Credit card accepted · For research & educational use only — not for human consumption.
Half-Life
~30 min plasma, but sustained GH/IGF-1 elevation
Common Dose
1–2 mg per day
Route
Subcutaneous injection (abdomen)
Frequency
Once daily
Mechanism of Action
Tesamorelin binds to GHRH receptors on the pituitary, stimulating natural pulsatile GH release. The resulting elevation in GH and IGF-1 supports lipolysis (especially visceral fat breakdown), lean muscle preservation, improved skin and tissue quality, and neurocognitive benefits. Unlike CJC-1295 no DAC, it has a longer half-life and produces stronger sustained GH elevation.
Reported Benefits
- ✦Significant reduction in visceral fat
- ✦Lean muscle preservation/growth
- ✦Improved cognition and memory (studied in HIV patients)
- ✦Better skin elasticity and quality
- ✦Improved sleep and recovery
- ✦Lowered triglycerides
- ✦FDA-approved (in HIV lipodystrophy)
Side Effects
- !Injection site reactions (most common)
- !Joint pain or stiffness
- !Water retention
- !Numbness or tingling in hands/feet
- !Mild glucose elevation
- !Headache
- !Increased IGF-1 (monitor levels)
Dosage Protocol
Notes
10 mg vial — reconstitute with 2 mL bac water → 5 mg/mL: 20 units (0.2 mL) = 1 mg. Cycle 8–12 weeks. Consider monitoring IGF-1 and fasting glucose periodically. Best taken on empty stomach.
Research Status
FDA-approved for HIV lipodystrophy (as Egrifta). Off-label use for general body composition and cognitive benefits.
Contraindications
- ✕Active malignancy
- ✕Pregnancy and breastfeeding
- ✕Diabetic retinopathy
- ✕Known hypersensitivity
- ✕Pituitary disease
Storage
Lyophilized: refrigerate. Reconstituted: refrigerate, use within 30 days.
Legal Status
FDA-approved as Egrifta for HIV lipodystrophy. Off-label and research use otherwise.
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