Tirzepatide
Also known as: Mounjaro, Zepbound, LY3298176
Tirzepatide is a dual GLP-1 / GIP receptor agonist developed by Eli Lilly and FDA-approved as Mounjaro (for type 2 diabetes) and Zepbound (for weight loss). In clinical trials, it produced ~15–22% body weight reduction — the most effective weight-loss medication approved to date. Used for type 2 diabetes, obesity, and metabolic syndrome.
Research Use Only
Pricing
10-Pack Bundle Save 20%
Credit card accepted · For research & educational use only — not for human consumption.
Half-Life
~5 days
Common Dose
Start 2.5 mg/week, titrate up by 2.5 mg every 4 weeks to 5–15 mg/week
Route
Subcutaneous injection (abdomen
Frequency
Once weekly subcutaneous injection
Mechanism of Action
Tirzepatide activates two receptors simultaneously: GLP-1 (suppresses appetite, slows gastric emptying, improves insulin secretion) and GIP (enhances insulin sensitivity and supports fat metabolism). The dual-agonist effect produces greater weight loss and glycemic control than GLP-1 monotherapy (e.g., Semaglutide).
Reported Benefits
- ✦Significant weight loss (~15–22% body weight)
- ✦Excellent blood sugar control
- ✦Reduced appetite and cravings
- ✦Improved insulin sensitivity
- ✦Cardiovascular risk reduction
- ✦Better lipid profile
- ✦FDA-approved for type 2 diabetes and obesity
Side Effects
- !Nausea (especially during dose escalation)
- !Vomiting and diarrhea
- !Constipation
- !Decreased appetite
- !Fatigue
- !Possible gallbladder issues
- !Hair shedding (with rapid weight loss)
- !Risk of pancreatitis (rare)
- !Injection site reactions
Dosage Protocol
Notes
5 mg vial — reconstitute with 2 mL bac water → 2.5 mg/mL: 4 units (0.04 mL) = 100 mcg (so 100 units = 2.5 mg). Always titrate slowly to minimize GI side effects. Pair with adequate protein intake (1g/lb body weight) and resistance training to preserve muscle mass during weight loss.
Research Status
FDA-approved (Mounjaro / Zepbound). Multiple ongoing trials for additional indications including heart failure and NASH.
Contraindications
- ✕Personal/family history of medullary thyroid carcinoma
- ✕MEN2 syndrome
- ✕Pregnancy and breastfeeding
- ✕Severe gastroparesis
- ✕Pancreatitis history
Storage
Lyophilized: refrigerate. Reconstituted: refrigerate, use within 30 days.
Legal Status
FDA-approved prescription drug (Mounjaro for diabetes, Zepbound for weight loss).
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