Epithalon
Also known as: Epitalon, Epithalone, AEDG Peptide
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Russian gerontologist Vladimir Khavinson, based on the natural pineal peptide epithalamin. It is one of the most well-known anti-aging peptides, primarily studied for its ability to lengthen telomeres, normalize melatonin production, and extend healthspan in animal models. Often run in short annual courses.
Research Use Only
Pricing
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Credit card accepted · For research & educational use only — not for human consumption.
Half-Life
Short (~30 min), but biological effects persist much longer
Common Dose
5–10 mg per day for 10–20 day cycles
Route
Subcutaneous injection
Frequency
Once daily for 10–20 consecutive days
Mechanism of Action
Epithalon stimulates telomerase activity, the enzyme that maintains telomere length on chromosomes. By extending telomeres, it helps preserve cellular replication capacity and delay senescence. It also normalizes melatonin secretion from the pineal gland, restoring circadian rhythms, and modulates several pro-longevity gene expression pathways.
Reported Benefits
- ✦Telomere lengthening / telomerase activation
- ✦Normalized melatonin production
- ✦Improved sleep quality and circadian rhythm
- ✦Anti-aging effects on skin and immune function
- ✦Antioxidant properties
- ✦Potential lifespan extension (animal studies)
- ✦Improved energy and overall well-being
Side Effects
- !Very well-tolerated in studies
- !Mild injection site irritation
- !Rare lightheadedness
- !No significant adverse effects reported
Dosage Protocol
Notes
10 mg vial — reconstitute with 2 mL bac water → 5 mg/mL: 20 units (0.2 mL) = 5 mg. Typical protocol: 5–10 mg daily for 10–20 days, repeated 1–2 times per year. Most users run a 10–20 day course rather than continuous daily use.
Research Status
Decades of Russian research including human trials showing improved biomarkers of aging. Limited Western clinical data.
Contraindications
- ✕Pregnancy and breastfeeding
- ✕Active malignancy (telomerase activation theoretical concern)
- ✕Known hypersensitivity
Storage
Lyophilized: refrigerate. Reconstituted: refrigerate, use within 30 days.
Legal Status
Research chemical. Not approved for human therapeutic use.
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