KPV
Also known as: Lys-Pro-Val, α-MSH (11-13)
KPV is a small tripeptide (Lysine-Proline-Valine) that is the C-terminal fragment of alpha-MSH (alpha-melanocyte-stimulating hormone). It carries the potent anti-inflammatory and immunomodulatory activity of alpha-MSH without the pigmentation effects. KPV is particularly known for gut inflammation control, skin conditions, and the gut-skin axis.
Research Use Only
Pricing
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Credit card accepted · For research & educational use only — not for human consumption.
Half-Life
~15–30 minutes
Common Dose
200–500 mcg per day
Route
Subcutaneous injection
Frequency
Once daily
Mechanism of Action
KPV enters cells and acts on melanocortin receptors (MC1R, MC3R), suppressing NF-kB signaling and pro-inflammatory cytokines (TNF-α, IL-6, IL-8). It reduces inflammation at the source of immune cell activation. Particularly effective on intestinal epithelial cells, which is why it is often used for IBD, leaky gut, and inflammatory bowel issues.
Reported Benefits
- ✦Powerful anti-inflammatory effects
- ✦Gut barrier repair and IBD/colitis support
- ✦Acne and skin inflammation reduction
- ✦Improves the gut-skin axis
- ✦Wound healing support
- ✦Anti-microbial activity
- ✦Generally very well-tolerated
Side Effects
- !Very well-tolerated
- !Mild injection site irritation
- !Rare GI upset
- !Limited side effect profile
Dosage Protocol
Notes
10 mg vial — reconstitute with 2 mL bac water → 5 mg/mL: 10 units (0.1 mL) = 500 mcg. Cycle 4–8 weeks.
Research Status
Several decades of research in inflammation, IBD, and dermatology. Not yet approved as a pharmaceutical.
Contraindications
- ✕Pregnancy and breastfeeding
- ✕Active autoimmune conditions requiring intact inflammatory response
- ✕Known hypersensitivity
Storage
Lyophilized: refrigerate. Reconstituted: refrigerate, use within 30 days.
Legal Status
Research chemical. Not approved for human therapeutic use.
Commonly Stacked With
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