MOTS-c
Also known as: Mitochondrial Open Reading Frame of the 12S rRNA-c
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded by the mitochondrial genome. It acts as a hormonal regulator of metabolic homeostasis, with powerful effects on insulin sensitivity, exercise performance, and metabolic health. MOTS-c levels decline with age, and supplementing has been linked to anti-aging, fat loss, and improved energy.
Research Use Only
Pricing
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Credit card accepted · For research & educational use only — not for human consumption.
Half-Life
Short in plasma; biological effects last much longer
Common Dose
5–10 mg per week
Route
Subcutaneous injection
Frequency
5 days on / 2 off
Mechanism of Action
MOTS-c activates AMPK (AMP-activated protein kinase) — the body's master metabolic sensor — increasing glucose uptake, fatty acid oxidation, and mitochondrial biogenesis. It improves insulin sensitivity in muscle, reduces fat accumulation, and mimics many of the benefits of exercise at the cellular level. It also modulates nuclear gene expression for metabolic and stress-response genes.
Reported Benefits
- ✦Improved insulin sensitivity and glucose control
- ✦Enhanced fat loss, especially visceral fat
- ✦Increased exercise capacity and endurance
- ✦Mitochondrial biogenesis
- ✦Anti-aging metabolic effects
- ✦Reduced inflammation
- ✦Better energy and recovery
Side Effects
- !Generally well-tolerated
- !Injection site irritation
- !Mild fatigue (initial)
- !Possible mild hypoglycemia at high doses
Dosage Protocol
Notes
10 mg vial — reconstitute with 1–2 mL bac water. Standard protocol: ~10 mg per week split into 2–3 doses, or daily lower doses (5 days on / 2 off). Cycle 4–8 weeks with breaks.
Research Status
Active research in metabolic disease, exercise physiology, and aging.
Contraindications
- ✕Severe hypoglycemia risk
- ✕Pregnancy and breastfeeding
- ✕Known hypersensitivity
Storage
Lyophilized: refrigerate. Reconstituted: refrigerate, use within 30 days.
Legal Status
Research chemical. Not approved for human therapeutic use.
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